HELIXTURNHELIX (HTH)
HELIXTURNHELIX. This algorithm identifies the helix-turn-helix motif, which is known to be a Nucleic Acid Binding Motif. The helix-turn-helix motif was originally identified as the DNA-binding domain of phage repressors. One alpha-helix lies in the wide groove of DNA; the other lies at an angle across DNA. Part of EMBOSS.
HELIXTURNHELIX Algorithm Dodd, IB, Egan, JB (1990) "Improved detection of helix-turn-helix DNA-binding motifs in protein sequences." Nucl. Acids Res. 18(17): 5019–5026.
If you use EMBOSS, please cite: Rice, P, Longden, I, and Bleasby, A (2000) " EMBOSS: The European Molecular Biology Open Software Suite" Trends in Genetics 16, (6) 276--277. Original program "HELIXTURNHELIX" (EGCG 1990) by Peter Rice (pmr © ebi.ac.uk)
Manual: http://embossgui.sourceforge.net/demo/manual/helixturnhelix.html
INPUT = Protein Sequences.
TEST INPUT FILES
Input file: hth_input1.txt
TEST OUTPUT FILES
Output file: hth_output1.txt
